- Joint or coordinated sequencing (WGS), as described under Scope.
- New WGS data for a large number of representative European citizens, to be further specified in the call document, generated in accordance with the guidance, specifications and standards agreed within 1+MG (1+MG Trust Framework).
- Integration of eligible population-based WGS data generated independently of the GoE and made available to the project.
- The Genome of Europe federated reference database established and accessible through the federated European genomic data infrastructure and the European Health Data Space (EHDS) infrastructure for secondary use of health data (HealthData@EU).
This action will support the implementation of the Genome of Europe (GoE) multi-country project and contribute to achieving the objectives and long-term ambition of the 1+Million Genomes (1+MG) initiative. GoE aims to establish and launch a European reference genome database of genetic variation obtained by whole genome sequencing (WGS) for at least 500,000 citizens based on population-based national reference genome collections, collectively representative of the European population. GoE has the potential to foster break-through advances in research, innovation, disease prevention and healthcare delivery, widely spread across clinical disciplines, beyond current use cases (disease areas). Moreover, creation of a reference database will allow meaningful savings in healthcare systems as it will
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